Archive for October, 2007

Wyeth Brags Next CEO Found Without ‘Public Horse Race’

“Perhaps the timing caught some of you by surprise because we didn’t engage in the drama of a public horse race for succession that some of our competitors have been involved in,” Wyeth CEO and short-timer Robert Essner told analysts this morning during an earnings call.

He was comparing his company’s decision to name Bernard Poussot as Essner’s replacement with the recent high-profile bake-offs at GlaxoSmithKline and Pfizer. Despite the lack of public fanfare, Essner said, the selection process started five years ago and “involved a thorough and long-term evaluation of the character, track record, and potential of several candidates,” according to a transcript of the call from Thomson Financial.

Poussot himself spoke on the call, suggesting a recent loss in a legal fight over the company’s heartburn drug Protonix doesn’t mean the company is in immediate risk of generic competition. “For the time being we see no commercial activity on this front,” Dow Jones Newswires reports.

Some observers had speculated that Wyeth might settle with Teva and Sun, the generics companies Wyeth is fighting in the case. But Poussot’s comments indicate Wyeth may be in no hurry to settle.

His remarks came as the company announced third-quarter earnings. Revenue was up compared with the year-earlier period, but earnings were down because of special charges that included closing a factory.

The earnings were yet another sign that vaccines and biologicals are where the growth is in the industry. Sales of Wyeth’s vaccine Prevnar rose 24%. And sales of Enbrel, a biotech drug for arthritis and other conditions that Wyeth co-markets with Amgen, were up 39%.

Merck Diabetes Drug Gets New Uses, Warnings

Merck’s diabetes drug Januvia has been approved by the FDA for use in combination with older diabetes medicines, but stiffer warnings have also been added to the Januvia’s label.

The instructions now say allergic reactions and cases of a rare skin called Stevens-Johnson syndrome have been reported in some patients taking the drug. An FDA spokeswoman told the WSJ “the level of concern is not great.” And John Buse, the American Diabetes Association’s president for medicine and science, called the additional label information “par for the course.”

Still, Stevens-Johnson can be devastating for patients and is a particularly vexing problem for drug makers. A consortium of big drug makers said last month they’d be teaming up to look for genetic clues to better understand who might be at risk.

The reports of Stevens-Johnson and other skin reactions in patients taking Januvia also call to mind Novartis’s Galvus, a drug in the same class as Januvia that’s been delayed by the FDA in part because of skin reactions in monkeys. But John Amatruda, Merck’s VP of clinical research, said Merck hadn’t seen such reactions in its trial of Januvia, and added that there is “no evidence at all” that reactions in Januvia patients are related to those events.

The new approval says Januvia can now be prescribed with the diabetes drug metformin and a class of diabetes medicines called sulfonylureas.

Ejaculate Daily Can Increase The Chances Of Getting Better Sperm

Sex works on the principle of positive feed back: more sex just improves our ‘performance’. A team from Sydney University says that men with damaged sperm should have sex daily to increase the chances of getting their partner pregnant. In many cases, couples with fertility issues abstain from sex for several days to boost sperm numbers before trying to conceive.
Ejaculate Daily To Increase The Chances Of Getting Better Sperm
But the new research claims that this could mean lower-quality sperm. The Australian team investigated 42 men whose sperm had been discovered to have an abnormal shape after microscopical investigations. The subjects were required to ejaculate each day for seven days, and these sperms were compared with those collected from them after three days of abstinence.

Except for five cases, all the subjects presented less sperm damage in their samples coming after daily ejaculation, compared to the post-abstention samples. Dr Allan Pacey, the secretary of the British Fertility Society, agrees that daily sex could improve sperm quality in men with sperm issues.

“While not having sex allowed the numbers of sperm to build up, there was a “trade-off” between quality and quantity. This research shows that when you put people on a daily ejaculation regime, it reduces the figure for DNA damage. If you can go from 30% to 20% that is quite a big shift and that should have some implications for fertility. There are men out there who think, or whose partners think, that limiting ejaculation will make them more fertile.”, said Pacey.

“I remember one couple in which the woman would only let the man ejaculate when she was in her fertile period, so the poor chap was going without for almost a month at a time. If a couple was initially trying to get pregnant, an interval of two to three days was probably advisable - whereas a man with high DNA damage and a “decent” sperm count should try more often.”, he added.

(Content By Stefan Anitei For SoftPedia)

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Obesity Linked To Cancer,Maintaining Normal Weight Could Diseases Prevention

Obese people are six times more vulnerable to gullet (esophageal) cancer than people of average weight, as found by a recent British research.

Obesity Linked to Cancer

For years, doctors have said that being overweight is dangerous to your health. We have become more aware of the fact that obesity causes heart issues, hypertension, stroke and diabetes.Now Obesity has been linked to cancer.

Levels of esophageal cancer have been rapidly increasing and in some countries even faster than those of any other major type of cancer. The research team compared about 800 people with esophageal cancer and 1600 randomly selected healthy subjects. Men and people under the age of 50 were the most vulnerable categories to this disease.

The acid reflux and gullet cancer connection was well known, and unsurprisingly, repeated episodes of severe heartburn or gastrointestinal reflux disease (GORD) were linked to a much higher risk of the cancer. The more frequent the symptoms, the higher the probability of developing esophageal cancer.

GORD increased the probability of esophageal cancer by 5 times, but a combination of obesity and GORD boosted the chances of developing it by 16 times.

Subjects who were clinically obese presented a much higher risk of esophageal cancer than those with a “healthy” weight, no matter if they had GORD or not. People with a body mass index (BMI) of at least 40 were six times more prone to develop the cancer as those with a BMI of 18.5 to 25. The results remained valid even after considering other factors connected to this disease, like smoking and high alcohol intake. (BMI Calculator - Calculate Your BMI And Keep Your Body Healthy

“This suggests that obesity is an independent risk factor for the disease,” wrote the authors.

Higher amounts of fat tissue in the body increase insulin synthesis, which in turn boosts the levels of circulating insulin-like growth factor.

“Both these hormones stimulate cell growth and curb cell death, conditions which favor the development of cancers. Fat cells also produce other hormones, collectively known as adipocytokines, which speed up cell growth and are involved in inflammatory processes in the body,” wrote the authors.

(Content By Stefan Anitei for SoftPedia)

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10 Unusual Symptoms To Mostly Common Ailments

When exposed to a constant diet of disease-related information, it is not uncommon for medical students to develop a form of hypochondria called medical student syndrome. And though no one has coined a term for the tendency to self-diagnose rare diseases on the basis of a symptom and an Internet search, the proliferation of health-related information available in the news and on the Web has led many a health consumer to mentally leap from a dull ache to certain death. Common symptoms usually point to common problems, but that doesn’t diminish our fascination with the subtle, unusual clues our bodies may be sending us. Following are some unlikely symptoms that may send an early warning of trouble ahead. But reader beware: Sometimes a lump is only a lump.

The truly bizarre

The truly bizarre
And, finally, thank goodness if you don’t have the symptoms of what is currently called Morgellons disease. It’s not common—it doesn’t even have an “official” name yet—but it does have some very strange symptoms: “a range of cutaneous (skin) symptoms including crawling, biting and stinging sensations; granules, threads, fibers or black speck-like materials on or beneath the skin,” according to the Centers for Disease Control and Prevention. In fact, some with the affliction say that the fibers can be white, blue, black and red, and can be as thick as a spaghetti strand. Pulling them out causes searing pain.

Zzzzs mean disease?

Zzzzs mean disease?
Some of the strangest symptoms might be the most simple. In this case: sleepiness. That’s right—if you have persistent sleepiness, it might be a sign that you have narcolepsy. Many think of the more cinematic symptom of cataplexy, the sudden loss of muscle control that can include temporary paralysis. But it’s not the most common sign. And, if you think narcolepsy is a rare condition, experts estimate that it’s as common as MS.

Nailing diabetes?

Nailing diabetes?
Does it smell like nail polish remover even though there’s none around? Does your partner think he or she is kissing a bottle of it when you get intimate? It could be a sign that you have diabetes. Acetone, the major ingredient in polish remover, is found naturally in the body. However, when your body does not have enough insulin, or can’t make use of it, fat is used for energy instead of glucose, and acetone levels rise. In fact, the medical profession and researchers have known about acetone breath for ages. In August, two researchers from Mississippi State University published a study on their new medical device that uses the acetone in breath to detect early-stage diabetes.

Sniffing out Alzheimer’s

Sniffing out Alzheimer’s
Does a rose suddenly not smell as sweet? This unfortunate occurrence could be a symptom of a cold—or it could be an early sign of Alzheimer’s disease. Researchers have recently linked problems with the proboscis with a protein linked to Alzheimer’s. By the way, loss of smell could also be a warning sign for Parkinson’s disease or multiple sclerosis.

An eye on MS?

An eye on MS?
Speaking of MS, you might “see” you have it long before other symptoms present themselves. Often, blurred or double vision, red-green color distortion or even blindness in one eye is the first sign of the disease. Optic neuritis, the inflammation or demyelination of the optic nerve that causes blurring or loss of vision usually in one eye, indicates eventually developing MS in 40 percent of those experiencing the symptom. However, blurry vision is also a possible sign of diabetes—or maybe just a hangover.

Epilepsy in sight?

Epilepsy in sight?
And there’s more to consider if you’re having sight issues. You might have heard those of a New Age bent talk about “auras,” but a different kind of visual aura could be a sign of epilepsy. This visual hallucination can actually be a sign of seizure that’s less commonly thought of in connection with the disease. These “smaller” temporal-lobe seizures might also be accompanied by a sense of déjà vu and repetitive lip-smacking.

Armed against Parkinson’s

Armed against Parkinson’s
In the realm of strange physical symptoms, Parkinson’s disease has many. But one in particular is an early and easily detectable possible sign—an arm that doesn’t swing when you walk. This automatic movement, like blinking, can be diminished or lost with the onset of Parkinson’s. Scientists have discovered that with the disease, dopamine-releasing nerve-cell destruction causes difficulties with motion. Dopamine normally transmits signals that produce smooth controlled movement.

Heeling back pain

Heeling back pain
There’s a stabbing pain in your heel, which might seem odd considering that you’re not a runner. But, you might have a fairly common and painful problem—a herniated disc. Heel pain in this case is caused by the sciatic nerve, which runs from the back to the heel. In some cases the pain might run down the entire leg, but—even stranger—it might also just be felt in the heel.

Don’t jaw about it

Don’t jaw about it
At the other end of the body, don’t fool around with jaw pain—it could just save your life. One of the stranger signs of heart attack, jaw pain could be the early warning sign that gives you enough time to find help before it’s too late. The discomfort is really radiating from the chest, and might also be felt in the back and arms.

Twitchy about ALS?

Twitchy about ALS?
Amyotrophic lateral sclerosis, or Lou Gehrig’s disease, is a devastating disease that might present itself with the most banal of symptoms—muscle twitching or cramping. ALS is a neurodegenerative disease that causes nerve destruction and, hence, degeneration of muscle control. Another early sign of the disease is painless weakness in one hand.

Now, while having any of the above symptoms might be worth checking out, running to the doctor because you have a muscle twitch might be overreacting. As Dr. Edward Garbacz, an Atlanta-based board-certified internist says, “Doctors know—and patients should believe—that there is no one symptom that is predictive of one particular condition however serious or benign. For example, jaw pain is much more likely to be an indication of temporomandibular joint syndrome or a dental problem than it is for heart attack,” he says. “For peace of mind, the point is to associate any unusual symptoms with their more common causes. And by all means, seek the help of your health care practitioner for more persistent and personally disturbing symptoms.”

(Content By Bryce Edmonds For Msn)

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